Title: CocycleHunter: a topological tool for phase estimation in single-cell RNA-seq data
Abstract: In this talk I will introduce CocycleHunter, a tool for identifying and exploiting circular structure in single-cell RNAseq data, based on persistent cohomology in dimension one. Our method produces a system of statistically enriching gene sets for circular structure and provides a powerful, cohomology-based technique for estimating the phase of genes exhibiting cyclic expression patterns (gene cascades), which has been validated on synthetic RNA transcription models, as well as on real datasets related to the cell cycle, tissue re-generation, and senescence in diverse experimental conditions.
This is joint work, led by Kelly Maggs and Markus Youssef, with the collaboration of Cyril Pulver, Jovan Isa, Tâm Nguyên, Wouter Karthaus, and Paolo Dotto.
About the speaker: https://www.epfl.ch/labs/hessbellwald-lab/hessbellwald/
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