Title: What can identifiable models tell us about regulation of the cell cycle? 

Abstract: The spatiotemporal coordination and regulation of cell proliferation is fundamental in many aspects of development and tissue maintenance. Cells can adapt their division rates in response to mechanical checkpoints, yet we do not fully understand how cell proliferation regulation impacts collective cell migration phenomena. I will present a suite of continuum models of collective cell migration with cell cycle dynamics, which differ in their ability to describe mechanical constraints and hence cell proliferation regulation. By combining these mathematical models, Bayesian inference, and recent experimental data, I evaluate the level of model complexity that is consistent with the data and quantify the impact of mechanical constraints across different cell cycle stages in epithelial tissue expansion experiments. The modelling results predict that cells sense local density and adapt cell cycle progression in response, both during G1 and the combined S/G2/M phases, and provide an explicit relationship between each cell cycle stage duration and local tissue density. 

About the speaker: https://www.iamruthbaker.com/ 

Video of the talk: https://youtu.be/4rbXpcq4wXM