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  • Irène Vignon-Clémentel (INRIA, France)

Irène Vignon-Clémentel (INRIA, France)

  • 31 Jan 2024
  • Virtual

Title: Blood circulation in the liver: reduced models at the micro- and macroscales for disease understanding and surgical planning. 

Abstract: The liver is an essential organ, which is perfused by two entering flow networks, which merge in the organ functional units, called lobules. It is then drained by a single vessel network. Adequate perfusion is necessary for a proper liver function. We will present here how different rheological processes and network geometry impact perfusion in these lobules, to select relevant mathematical reduced models depending on the application. Transport of species builds on perfusion, and will also be analyzed, with a dedicated numerical scheme. The curative treatment of some liver diseases is its resection. It can induce drastic changes of perfusion and pressure, to the point of liver failure. Reduced models of blood flow at the organ level are a promising way to predict the associated surgical risk. We will present in particular sensitivity analysis studies relevant for patient-specific parameterization of the model.

More on the speaker: https://team.inria.fr/simbiotx/team-members/irene-vignon-clementel/

The link to the colloquium is shared with the ESMTB mailing list a few days before the colloquium.

Video of the talk: https://youtu.be/xmcTrV-3Pac

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